Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TYMP | P19971 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10917978 | 0.99 | ALDH1A1 (0.49) | ALDH1A1POLBMAPTMEN1LMNA | |
| SCHEMBL10918979 | 0.89 | ALDH1A1 (0.52) | ALDH1A1POLBMAPTMEN1LMNA | |
| SCHEMBL10920934 | 0.88 | TSHR (0.51) | ALDH1A1MAPTLMNAKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10922643 | 0.88 | POLB (0.42) | ALDH1A1POLBMAPTMEN1LMNA | |
| SCHEMBL10922313 | 0.83 | MEN1 (0.51) | ALDH1A1MAPTMEN1LMNAKMT2A | |
| SCHEMBL10914047 | 0.83 | HSD11B1 (0.50) | ALDH1A1LMNASMN1; SMN2HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL10916739 | 0.82 | HSD11B1 (0.49) | ALDH1A1LMNASMN1; SMN2HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL10921886 | 0.82 | KMT2A (0.58) | ALDH1A1POLBMAPTMEN1LMNA | |
| SCHEMBL10916090 | 0.82 | DRD2 (0.50) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL10919669 | 0.82 | NPC1 (0.50) | ALDH1A1MAPTMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064704-B1 | 4-AMINOMETHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4381393-A | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0064704-A1 | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |