Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10917978 | 0.91 | ALDH1A1 (0.49) | ALDH1A1LMNAKMT2AMEN1PDE3B | |
| Hydrochloric Acid SCHEMBL10922643 | 0.90 | POLB (0.42) | ALDH1A1LMNAKMT2AMEN1PDE3B | |
| SCHEMBL10916248 | 0.89 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL10920934 | 0.87 | TSHR (0.51) | ALDH1A1KDM4ELMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10922313 | 0.84 | MEN1 (0.51) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10919669 | 0.83 | NPC1 (0.50) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL10921886 | 0.83 | KMT2A (0.58) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10919861 | 0.82 | MAPT (0.58) | ALDH1A1KDM4EKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL10917805 | 0.82 | NPC1 (0.49) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL10914047 | 0.82 | HSD11B1 (0.50) | ALDH1A1KDM4ELMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064704-B1 | 4-AMINOMETHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4381393-A | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0064704-A1 | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |