Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10921886 | 0.86 | KMT2A (0.58) | DRD4ADORA1ALDH1A1LMNADRD2 | |
| SCHEMBL10915707 | 0.83 | MEN1 (0.51) | HTR1AHTR7KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL10919243 | 0.79 | ABCB1 (0.48) | HTR1AALDH1A1LMNAHTR7KDM4E | |
| SCHEMBL11189411 | 0.79 | MEN1 (0.57) | DRD4ALDH1A1LMNADRD2GAA | |
| Hydrochloric Acid SCHEMBL10921910 | 0.78 | MEN1 (0.56) | DRD4ALDH1A1LMNADRD2GAA | |
| SCHEMBL10922313 | 0.76 | MEN1 (0.51) | ALDH1A1LMNAMAPTL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL10915699 | 0.75 | SIGMAR1 (0.49) | HTR1ADRD4ALDH1A1LMNAHTR7 | |
| Hydrochloric Acid SCHEMBL10921255 | 0.72 | PDE3B (0.52) | HTR1AALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL10916832 | 0.72 | DRD2 (0.57) | HTR1ADRD4HTR7DRD2KMT2A | |
| Hydrochloric Acid SCHEMBL10921685 | 0.72 | ABCB1 (0.43) | HTR1ADRD4ALDH1A1LMNADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064704-B1 | 4-AMINOMETHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4381393-A | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0064704-A1 | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |