Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11530368 | 0.98 | GAA (0.39) | NAMPTCTSDGAAOGG1MAPT | |
| SCHEMBL11530576 | 0.98 | GAA (0.39) | NAMPTCTSDGAAOGG1MAPT | |
| SCHEMBL15144321 | 0.89 | GAA (0.42) | CTSDGAAOGG1MAPTTSHR | |
| SCHEMBL21658868 | 0.86 | GAA (0.45) | CTSDGAAOGG1MAPTTSHR | |
| SCHEMBL18045691 | 0.86 | GAA (0.45) | CTSDGAAOGG1MAPTTSHR | |
| SCHEMBL24116501 | 0.83 | ALDH1A1 (0.45) | CTSDGAAOGG1TSHRKDM4E | |
| SCHEMBL16420411 | 0.81 | ALDH1A1 (0.43) | CTSDGAAOGG1TSHRKDM4E | |
| SCHEMBL15010517 | 0.81 | GAA (0.47) | CTSDGAAMAPTTSHRCA2 | |
| SCHEMBL21162998 | 0.81 | CES2 (0.44) | CTSDGAAOGG1TSHRKDM4E | |
| SCHEMBL30951728 | 0.81 | GAA (0.47) | CTSDGAAMAPTTSHRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193148-A2 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1986-09-03 | — | — | EP | claimed |
| US-4559337-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | claimed |
| EP-3541802-B1 | ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2025-01-01 | — | — | EP | disclosed |
| CN-117615753-A | Lipid nanoparticle and method for preparing the same | 泰纳治疗公司 | 2024-02-27 | — | — | CN | disclosed |
| US-11191762-B2 | Alkyl substituted triazole compounds as agonists of the APJ Receptor | AMGEN INC. (US) | 2021-12-07 | — | — | US | disclosed |
| US-20190290647-A1 | ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2019-09-26 | — | — | US | disclosed |
| EP-0193148-A2 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1986-09-03 | — | — | EP | disclosed |
| US-4559337-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4178378-A | ANTIEPILEPTIC AGENT, TRANQUILIZER, AND ANTICONVULSANT | CIBA-GEIGY CORPORATION (US) | 1979-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11191762-B2 | Alkyl substituted triazole compounds as agonists of the APJ Receptor | AGTR1, AGTR2, APLNR | NAMPT 4120/4885CTSD 4599/4885GAA 4711/4885 |
| US-20190290647-A1 | ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AGTR1, AGTR2, APLNR | NAMPT 4120/4885CTSD 4599/4885GAA 4711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.