Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.63 |
| ▸ | RAB9A | P51151 | 9/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 7/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926602 | 0.91 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2TDP1CASP3 | |
| SCHEMBL10925299 | 0.88 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TDP1CASP3 | |
| SCHEMBL10925607 | 0.79 | CXCL8 (0.43) | NPC1RAB9ASMN1; SMN2TSHRMAPK1 | |
| SCHEMBL2069650 | 0.78 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2TDP1CASP3 | |
| SCHEMBL10904041 | 0.77 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2TSHRMAPK1 | |
| SCHEMBL10928290 | 0.77 | AKR1C3 (0.40) | NPC1RAB9ASMN1; SMN2TDP1CASP3 | |
| SCHEMBL10923821 | 0.75 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2TSHRMAPK1 | |
| SCHEMBL10925514 | 0.74 | TSHR (0.41) | NPC1RAB9ASMN1; SMN2TDP1TSHR | |
| SCHEMBL2069336 | 0.73 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2TDP1CASP3 | |
| SCHEMBL29923454 | 0.73 | NFKB1 (0.60) | NPC1RAB9ASMN1; SMN2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189080-A2 | (1,2,4-Oxadiazol-3-YL)-arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-30 | — | — | EP | disclosed |
| US-4562186-A | HYPOTENSIVE, ANALGESICS, AND ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |