Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923821 | 0.89 | ALDH1A1 (0.42) | LMNAALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL10922342 | 0.89 | LTA4H (0.39) | MAPTSMN1; SMN2GRM5TSHRMEN1 | |
| SCHEMBL10925925 | 0.88 | MAPT (0.41) | LMNAMAPTSMN1; SMN2AKR1B1TSHR | |
| SCHEMBL10925607 | 0.88 | CXCL8 (0.43) | LMNAALDH1A1MAPTSMN1; SMN2CXCL8 | |
| SCHEMBL10925296 | 0.79 | ATM (0.39) | ALDH1A1MAPTSMN1; SMN2TDP1TSHR | |
| SCHEMBL10926847 | 0.76 | MAPT (0.43) | LMNAALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL10925378 | 0.76 | KMT2A (0.44) | ALDH1A1MAPTSMN1; SMN2AKR1B1MEN1 | |
| SCHEMBL10926174 | 0.76 | LMNA (0.44) | LMNAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL10922810 | 0.75 | TSHR (0.48) | LMNAALDH1A1MAPTSMN1; SMN2PTGS2 | |
| SCHEMBL10926682 | 0.74 | MAPT (0.51) | LMNAALDH1A1MAPTSMN1; SMN2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189080-A2 | (1,2,4-Oxadiazol-3-YL)-arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-30 | — | — | EP | disclosed |