Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926631 | 0.88 | LMNA (0.39) | LMNAALDH1A1SMN1; SMN2TDP1P2RY14 | |
| SCHEMBL10927504 | 0.80 | SMN1; SMN2 (0.40) | LMNAALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL10925514 | 0.80 | TSHR (0.41) | LMNAALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL10924333 | 0.80 | TSHR (0.40) | LMNAALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL10926847 | 0.78 | MAPT (0.43) | LMNAALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL10923821 | 0.78 | ALDH1A1 (0.42) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10922342 | 0.78 | LTA4H (0.39) | SMN1; SMN2NPC1RAB9AMAPTHTT | |
| SCHEMBL10925925 | 0.77 | MAPT (0.41) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10925607 | 0.77 | CXCL8 (0.43) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10922810 | 0.77 | TSHR (0.48) | LMNAALDH1A1SMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189080-A2 | (1,2,4-Oxadiazol-3-YL)-arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-30 | — | — | EP | disclosed |