Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.35 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933041 | 0.96 | CA12 (0.47) | CA12CA1CA2CA9POLB | |
| SCHEMBL10938620 | 0.80 | FPR2 (0.43) | CA12CA1CA2CA9POLB | |
| Potassium Ion SCHEMBL10934871 | 0.80 | CA12 (0.44) | CA12CA1CA2CA9POLB | |
| SCHEMBL28686955 | 0.75 | POLB (0.46) | POLBMAPTMMEKDM4ETHRB | |
| SCHEMBL15328463 | 0.75 | POLB (0.54) | CA1CA2POLBMAPTMME | |
| SCHEMBL28670626 | 0.75 | POLB (0.46) | POLBMAPTMMEKDM4ETHRB | |
| SCHEMBL31410761 | 0.75 | POLB (0.44) | POLBMAPTMMEKDM4ETHRB | |
| SCHEMBL27827362 | 0.75 | POLB (0.44) | POLBMAPTMMEKDM4ETHRB | |
| Lithium Ion SCHEMBL28670629 | 0.75 | POLB (0.43) | CA1CA2POLBMAPTMME | |
| SCHEMBL1704966 | 0.73 | MAPT (0.64) | POLBMAPTMMEKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4554108-A | Alkali carboxyalkyl dithiocarbamates and use as ore flotation reagents | PHILLIPS PETROLEUM COMPANY (US) | 1985-11-19 | — | — | US | claimed |
| CN-110035829-B | Depressant composition and method for depressing gangue sulfide minerals during flotation of sulfide ores | 塞特工业公司 | 2021-12-24 | — | — | CN | disclosed |
| US-10710099-B2 | Compositions and methods for selective separation of minerals from sulfide ores | CYTEC INDUSTRIES INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190336984-A1 | COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF MINERALS FROM SULFIDE ORES | CYTEC INDUSTRIES INC. (US) | 2019-11-07 | — | — | US | disclosed |
| US-10369577-B2 | Compositions and methods for selective separation of minerals from sulfide ores | CYTEC INDUSTRIES INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180099293-A1 | COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF MINERALS FROM SULFIDE ORES | CYTEC INDUSTRIES INC. | 2018-04-12 | — | — | US | disclosed |
| US-4554068-A | DITHIOCARBAMATES AS SUPPRESSANTS | PHILLIPS PETROLEUM COMPANY (US) | 1985-11-19 | — | — | US | disclosed |
| US-4554108-A | Alkali carboxyalkyl dithiocarbamates and use as ore flotation reagents | PHILLIPS PETROLEUM COMPANY (US) | 1985-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10369577-B2 | Compositions and methods for selective separation of minerals from sulfide ores | TST, CTH, PFAS | CA12 506/4885CA1 67/4885CA2 46/4885 |
| US-20190336984-A1 | COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF MINERALS FROM SULFIDE ORES | TST, CTH, PFAS | CA12 506/4885CA1 67/4885CA2 46/4885 |
| US-10710099-B2 | Compositions and methods for selective separation of minerals from sulfide ores | TST, CTH, PFAS | CA12 506/4885CA1 67/4885CA2 46/4885 |
| US-20180099293-A1 | COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF MINERALS FROM SULFIDE ORES | TST, CTH, PFAS | CA12 506/4885CA1 67/4885CA2 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.