Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 5/20 | 0.32 |
| ▸ | CA2 | P00918 | 5/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686957 | 0.96 | POLB (0.43) | POLBTGFBR1MMEKDM4EMAPT | |
| SCHEMBL28688354 | 0.82 | FPR2 (0.40) | TGFBR1MMENFKB1FOLH1NAALAD2 | |
| Potassium Ion SCHEMBL28676086 | 0.82 | FPR2 (0.40) | TGFBR1MMENFKB1FOLH1NAALAD2 | |
| SCHEMBL5475677 | 0.76 | CAD (0.44) | POLBTGFBR1MMEKDM4EMAPT | |
| Lithium Ion SCHEMBL10935110 | 0.75 | CA12 (0.47) | POLBTGFBR1MMEKDM4EMAPT | |
| Lithium Ion SCHEMBL28676082 | 0.75 | CA2 (0.41) | MMEKDM4EMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL345247 | 0.72 | TGFBR1 (0.41) | POLBTGFBR1MMEKDM4EMAPT | |
| SCHEMBL29211036 | 0.72 | TGFBR1 (0.41) | POLBTGFBR1MMEKDM4EMAPT | |
| SCHEMBL4614526 | 0.71 | CA12 (0.35) | KDM4ESMN1; SMN2CA1CA2 | |
| SCHEMBL16628445 | 0.71 | CA12 (0.35) | KDM4ESMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110035829-B | Depressant composition and method for depressing gangue sulfide minerals during flotation of sulfide ores | 塞特工业公司 | 2021-12-24 | — | — | CN | disclosed |