Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10937671 | 0.90 | MEN1 (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2ACCR2 | |
| SCHEMBL10935421 | 0.81 | MEN1 (0.49) | MEN1KMT2ATACR1SYKCCR2 | |
| SCHEMBL187309 | 0.81 | MEN1 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2ACCR2 | |
| SCHEMBL2845133 | 0.80 | MEN1 (0.50) | ALDH1A1MEN1KMT2ASYKCCR2 | |
| SCHEMBL2845134 | 0.80 | KDM4E (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2ASYK | |
| SCHEMBL9501543 | 0.78 | HTR7 (0.51) | MEN1KMT2AGRIN1GRIN2BPPARG | |
| Hydrochloric Acid SCHEMBL10734951 | 0.78 | MEN1 (0.53) | MEN1KMT2ACCR2PPARGPPARA | |
| SCHEMBL2930491 | 0.78 | CCR2 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2ACCR2 | |
| SCHEMBL1578403 | 0.78 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2ACCR2 | |
| SCHEMBL186303 | 0.78 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2ACCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |