Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.52 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149553 | 0.89 | ALDH1A1 (1.00) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL10939119 | 0.83 | RAB9A (0.77) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL10936334 | 0.79 | ALDH1A1 (0.57) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL1149220 | 0.78 | ALDH1A1 (0.76) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL8284046 | 0.77 | RAB9A (1.00) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL1428773 | 0.77 | RAB9A (0.67) | ALDH1A1RAB9AGAANPC1TSHR | |
| SCHEMBL70354 | 0.76 | BAZ2B (0.71) | ALDH1A1GAABAZ2BBAZ2ALMNA | |
| SCHEMBL10940550 | 0.76 | ALDH1A1 (0.61) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL1006532 | 0.75 | ALDH1A1 (0.76) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL3977780 | 0.75 | ALDH1A1 (0.67) | ALDH1A1RAB9AGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |