Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAD | Q92934 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190948 | 0.86 | SMN1; SMN2 (0.65) | POLBNPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL10939397 | 0.84 | ALDH1A1 (0.58) | POLBNPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL10938851 | 0.83 | HTT (0.64) | NPC1SMN1; SMN2PKMRAB9AHSP90AA1 | |
| SCHEMBL10936789 | 0.83 | SRD5A2 (0.58) | NPC1SMN1; SMN2PKMRAB9AHSP90AA1 | |
| SCHEMBL10938094 | 0.82 | L3MBTL1 (0.50) | POLBRAB9ANOTUML3MBTL1KMT2A | |
| SCHEMBL10938127 | 0.81 | DHODH (0.51) | NPC1SMN1; SMN2PKMRAB9AHSP90AA1 | |
| SCHEMBL10940646 | 0.81 | ALDH1A1 (0.55) | POLBNPC1RAB9AL3MBTL1HTT | |
| SCHEMBL15452710 | 0.78 | HTT (0.71) | POLBNPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL10938982 | 0.77 | KMT2A (0.51) | POLBNPC1SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL10940933 | 0.76 | MAPK14 (0.59) | POLBRAB9AL3MBTL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |