Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10937218 | 0.81 | ALPL (0.49) | ALDH1A1TP53CASP1SMN1; SMN2ERCC5 | |
| SCHEMBL5532565 | 0.79 | RORC (0.51) | ALDH1A1TP53TSHRSMN1; SMN2ALPL | |
| SCHEMBL8160214 | 0.78 | ALDH1A1 (0.71) | ALDH1A1TP53TSHRCASP1SMN1; SMN2 | |
| SCHEMBL224469 | 0.76 | ALDH1A1 (1.00) | ALDH1A1TP53F7F3TSHR | |
| SCHEMBL10939169 | 0.75 | SRD5A2 (0.59) | F7F3TSHRSMN1; SMN2CA1 | |
| 1,4-Dichlorobenzene SCHEMBL29282730 | 0.74 | ALDH1A1 (0.95) | ALDH1A1TP53F7F3TSHR | |
| SCHEMBL6584266 | 0.74 | ALDH1A1 (0.95) | ALDH1A1TP53F7F3TSHR | |
| Hydrochloric Acid SCHEMBL699002 | 0.74 | ALDH1A1 (0.95) | ALDH1A1TP53F7F3TSHR | |
| SCHEMBL3481659 | 0.73 | MAPT (0.59) | ALDH1A1TP53SMN1; SMN2ERCC5FEN1 | |
| SCHEMBL13401358 | 0.72 | ALDH1A1 (0.69) | ALDH1A1TP53TSHRCASP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |