Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TPMT | P51580 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874537 | 0.88 | SMN1; SMN2 (0.56) | POLBPARP1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL29190945 | 0.88 | SMN1; SMN2 (0.56) | POLBPARP1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL10941698 | 0.84 | GPR17 (0.47) | POLBPARP1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL10939397 | 0.83 | ALDH1A1 (0.58) | POLBNOTUMSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL10936789 | 0.82 | SRD5A2 (0.58) | NOTUMSMN1; SMN2TPMTALDH1A1RAB9A | |
| SCHEMBL10941754 | 0.81 | ALOX15 (0.51) | PARP1SMN1; SMN2TPMTALDH1A1RAB9A | |
| SCHEMBL10938094 | 0.81 | L3MBTL1 (0.50) | POLBNOTUMPARP1HDAC6ALDH1A1 | |
| SCHEMBL30874543 | 0.78 | ALDH1A1 (0.59) | POLBPARP1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL29191056 | 0.78 | ALDH1A1 (0.59) | POLBPARP1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL29382709 | 0.77 | PARP1 (0.65) | POLBPARP1SMN1; SMN2TPMTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |