Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940107 | 0.88 | NR4A2 (0.46) | NR4A2KDM4ELIPGBRD4GABRA1 | |
| SCHEMBL10940677 | 0.83 | BRD4 (0.43) | LIPGBRD4ALDH1A1MAPTGAA | |
| SCHEMBL25072433 | 0.79 | KDM4E (0.46) | NR4A2KDM4EBRD4ALDH1A1MAPT | |
| SCHEMBL10940971 | 0.77 | ACMSD (0.42) | LIPGBRD4CYP1A2MEN1ALDH1A1 | |
| SCHEMBL28554392 | 0.76 | KDM4E (0.44) | NR4A2KDM4EBRD4GABRA1GABRG2 | |
| SCHEMBL10940510 | 0.73 | NR4A2 (0.44) | NR4A2KDM4EBRD4GABRA1GABRG2 | |
| SCHEMBL17700915 | 0.71 | KDM4E (0.45) | NR4A2KDM4EBRD4CYP1A2PKM | |
| SCHEMBL11455034 | 0.70 | CDC25B (0.50) | NR4A2KDM4EBRD4MEN1ALDH1A1 | |
| Acetic Acid Methyl Ester SCHEMBL5167069 | 0.69 | ALDH1A1 (0.50) | CYP1A2CYP2C19MEN1ALDH1A1MAPT | |
| SCHEMBL9826739 | 0.69 | KDM4E (0.46) | NR4A2KDM4EBRD4MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |