Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940677 | 0.87 | BRD4 (0.43) | ACMSDBRD4LIPGKMOHNF4A | |
| SCHEMBL10940107 | 0.83 | NR4A2 (0.46) | BRD4LIPGMEN1ALDH1A1GAA | |
| SCHEMBL10940902 | 0.77 | NR4A2 (0.43) | BRD4LIPGCYP1A2MEN1ALDH1A1 | |
| SCHEMBL2781478 | 0.77 | NOTUM (0.41) | PTPN1CYP1A2NOTUMMEN1ALDH1A1 | |
| SCHEMBL9723823 | 0.75 | NOTUM (0.40) | PTPN1CYP1A2NOTUMMEN1ALDH1A1 | |
| SCHEMBL9635530 | 0.71 | ALDH1A1 (0.50) | PTPN1ALDH1A1KMT2A | |
| SCHEMBL31342301 | 0.71 | AKR1C3 (0.50) | NOTUMALDH1A1 | |
| SCHEMBL7853670 | 0.70 | NOTUM (0.37) | PTPN1CYP1A2NOTUMMEN1ALDH1A1 | |
| SCHEMBL3260481 | 0.70 | LIPG (0.45) | ACMSDLIPGHNF4AMCL1DHFR | |
| Acetic Acid SCHEMBL734741 | 0.70 | KMO (0.56) | ACMSDKMOPTPN1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |