Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067 | 0.82 | APP (0.65) | APPCYP1A2L3MBTL1GAAKDM4E | |
| SCHEMBL1096453 | 0.80 | APP (0.63) | APPCYP1A2L3MBTL1GAAKDM4E | |
| Water SCHEMBL1094033 | 0.80 | APP (0.63) | APPCYP1A2L3MBTL1GAAKDM4E | |
| SCHEMBL10145489 | 0.80 | APP (0.59) | APPCYP1A2L3MBTL1GAAKDM4E | |
| SCHEMBL1094100 | 0.80 | APP (0.59) | APPCYP1A2GPR119L3MBTL1KDM4E | |
| SCHEMBL23806150 | 0.79 | L3MBTL1 (0.47) | APPCYP1A2L3MBTL1GAAKDM4E | |
| SCHEMBL5085776 | 0.79 | APP (0.61) | APPCYP1A2L3MBTL1KDM4EMEN1 | |
| SCHEMBL1635563 | 0.78 | APP (0.68) | APPCYP1A2L3MBTL1GAAKDM4E | |
| SCHEMBL8066 | 0.78 | APP (1.00) | APPCYP1A2MEN1POLBKMT2A | |
| SCHEMBL14243596 | 0.78 | APP (0.68) | APPCYP1A2L3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216974-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9115099-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | UNIV WASHINGTON (US) | 2015-06-25 | — | — | US | disclosed |
| US-20140221647-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| US-8735575-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20120035359-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | THE WASHINGTON UNIVERSITY (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221647-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | APP 3242/4885CYP1A2 12/4885GPR119 4334/4885 |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | APP 3242/4885CYP1A2 12/4885GPR119 4334/4885 |
| US-20120035359-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | APP 3242/4885CYP1A2 12/4885GPR119 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.