Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.45 |
| ▸ | TMPRSS15 | P98073 | 10/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | FURIN | P09958 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10942391 | 0.99 | F2 (0.46) | F2F10PLAUPLGPLAT | |
| SCHEMBL7743635 | 0.87 | F2 (0.48) | F2F10PLAUPLGPLAT | |
| SCHEMBL10889487 | 0.87 | KMT2A (0.56) | F2F10PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL11144929 | 0.86 | KMT2A (0.55) | F2F10PLAUPLGPLAT | |
| SCHEMBL28094803 | 0.82 | MAPT (0.56) | CYP2D6CYP19A1CYP2C9CYP2C19KMT2A | |
| SCHEMBL10945116 | 0.80 | ALDH1A1 (0.57) | F2PLAUPRSS1TMPRSS15KMT2A | |
| SCHEMBL10492954 | 0.78 | PRSS1 (0.48) | F2F10PLAUPLGPLAT | |
| SCHEMBL10894177 | 0.76 | MAPT (0.62) | F2F10PLGKLK1KLK5 | |
| SCHEMBL7343416 | 0.76 | MEN1 (0.62) | F2F10PLAUPLGKLK1 | |
| Hydrochloric Acid SCHEMBL11144871 | 0.75 | MAPT (0.60) | F2F10PLGKLK1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091240-B1 | ENZYME DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1985-12-27 | — | — | EP | disclosed |
| US-4507283-A | STREPTOKINASE-HUMAN PLASMINOGEN ACTIVATOR COMPLEX BLOCKED BY A 2- OR 4-AMINOBENZOYL GROUP; ANTICOAGULANT | BEECHAM GROUP P.L.C. (GB) | 1985-03-26 | — | — | US | disclosed |
| EP-0091240-A2 | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-10-12 | — | — | EP | disclosed |