Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | CDC25A | P30304 | 2/20 | 0.42 |
| ▸ | CDC25B | P30305 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10951269 | 1.00 | PDE4B (0.42) | PDE4BCDC25ACDC25BMAPTALDH1A1 | |
| SCHEMBL10949178 | 0.81 | MAOB (0.44) | MAPTALDH1A1NPSR1MITFHTT | |
| SCHEMBL10952060 | 0.74 | MAPT (0.41) | CDC25ACDC25BMAPTALDH1A1NPSR1 | |
| SCHEMBL10954064 | 0.74 | MAPT (0.41) | CDC25ACDC25BMAPTALDH1A1NPSR1 | |
| SCHEMBL10946120 | 0.72 | KMT2A (0.50) | PDE4BCDC25ACDC25BMAPTALDH1A1 | |
| SCHEMBL20207728 | 0.68 | MAPT (0.43) | MAPTALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL18701282 | 0.68 | MAPT (0.39) | MAPTALDH1A1HTTKDM4ESMN1; SMN2 | |
| Mimosamycin SCHEMBL29884075 | 0.67 | CDC25A (0.46) | CDC25ACDC25BMAPTALDH1A1KDM4E | |
| SCHEMBL10952676 | 0.67 | ALDH1A1 (0.43) | CDC25ACDC25BMAPTALDH1A1NPSR1 | |
| SCHEMBL11429710 | 0.65 | LMNA (0.58) | MAPTALDH1A1HTTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |