Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058625 | 0.80 | MAP3K7 (0.36) | MAP3K7TAB1PARP10GSK3B | |
| SCHEMBL10959345 | 0.79 | PLAU (0.41) | ACACB | |
| SCHEMBL11061001 | 0.77 | MEN1 (0.35) | ACACBPARP10 | |
| SCHEMBL11061481 | 0.75 | PLAU (0.33) | ACACB | |
| SCHEMBL11060720 | 0.71 | CYP3A4 (0.36) | ACACB | |
| SCHEMBL11058688 | 0.71 | POLB (0.35) | — | |
| SCHEMBL11069404 | 0.69 | MAP3K7 (0.39) | ACACBMAP3K7TAB1PARP10GSK3B | |
| SCHEMBL29951713 | 0.67 | HSP90AA1 (0.32) | HSP90AA1HSP90B1 | |
| SCHEMBL6118193 | 0.67 | IRAK4 (0.54) | PARP10IRAK4 | |
| SCHEMBL11064906 | 0.67 | MAP3K7 (0.32) | MAP3K7TAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |