Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959345 | 0.84 | PLAU (0.41) | PLAUACACBGABRG2GABRB3GABRA2 | |
| SCHEMBL11061481 | 0.80 | PLAU (0.33) | MEN1KMT2APLAUACACBGABRG2 | |
| SCHEMBL11061001 | 0.79 | MEN1 (0.35) | MEN1KMT2AACACB | |
| SCHEMBL11064906 | 0.77 | MAP3K7 (0.32) | MEN1LMNAMAPTKMT2ACDK1 | |
| SCHEMBL11060675 | 0.74 | LMNA (0.33) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL11063674 | 0.73 | CYP3A4 (0.38) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL11058684 | 0.71 | LMNA (0.43) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL11059949 | 0.71 | ACACB (0.33) | ACACB | |
| SCHEMBL11060716 | 0.70 | MEN1 (0.36) | CYP3A4MEN1NR1I2LMNACHRM2 | |
| SCHEMBL11055926 | 0.69 | SMN1; SMN2 (0.35) | CYP3A4MEN1NR1I2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |