Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Prorenoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 known ✓ | P08235 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | PGR | P06401 | 5/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | AR | P10275 | 4/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.41 |
| ▸ | SHBG | P04278 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prorenoate SCHEMBL10959457 | 1.00 | TDP1 (0.65) | TDP1MEN1KMT2APGRNR3C1 | |
| Prorenoate SCHEMBL123301 | 1.00 | TDP1 (0.65) | TDP1MEN1KMT2APGRNR3C1 | |
| Prorenoate SCHEMBL19874033 | 0.90 | TDP1 (0.53) | TDP1MEN1KMT2APGRNR3C1 | |
| Prorenoate SCHEMBL638301 | 0.90 | TDP1 (0.53) | TDP1MEN1KMT2APGRNR3C1 | |
| Prorenoate SCHEMBL10959454 | 0.90 | TDP1 (0.52) | TDP1MEN1KMT2APGRNR3C1 | |
| Prorenoate SCHEMBL4265120 | 0.90 | TDP1 (0.52) | TDP1MEN1KMT2APGRNR3C1 | |
| SCHEMBL10961452 | 0.89 | TDP1 (0.51) | TDP1MEN1KMT2APGRNR3C1 | |
| SCHEMBL11645078 | 0.87 | PGR (0.51) | TDP1MEN1KMT2APGRNR3C1 | |
| SCHEMBL5978536 | 0.85 | PGR (0.53) | TDP1MEN1KMT2APGRNR3C1 | |
| SCHEMBL11640949 | 0.85 | PGR (0.53) | TDP1MEN1KMT2APGRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4542128-A | 17α-Pregn-4-ene-3-oxo-21-carboxylic acid esters, process for the preparation thereof, and use thereof as medicinal agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-09-17 | — | — | US | disclosed |