Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.49 |
| ▸ | HTR1B | P28222 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11570035 | 0.81 | SIGMAR1 (0.56) | SIGMAR1NCEH1KDM4EALDH1A1HPGD | |
| SCHEMBL6003215 | 0.80 | SIGMAR1 (0.54) | SIGMAR1LMNANCEH1ALDH1A1HPGD | |
| SCHEMBL11349063 | 0.77 | CHRNB2 (0.60) | LMNACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2090835 | 0.76 | SIGMAR1 (0.61) | SIGMAR1LMNANCEH1ALDH1A1TSHR | |
| SCHEMBL10963989 | 0.76 | ALDH1A1 (0.40) | SIGMAR1HTR1BKDM4EALDH1A1HPGD | |
| SCHEMBL27431595 | 0.75 | SIGMAR1 (0.59) | SIGMAR1LMNAKDM4EALDH1A1TSHR | |
| SCHEMBL2090833 | 0.75 | SIGMAR1 (0.59) | SIGMAR1LMNANCEH1 | |
| SCHEMBL11872011 | 0.73 | SIGMAR1 (0.65) | SIGMAR1LMNANCEH1CNR2 | |
| SCHEMBL5923592 | 0.73 | SIGMAR1 (0.56) | SIGMAR1LMNANCEH1KDM4E | |
| SCHEMBL995336 | 0.71 | CA12 (0.46) | SIGMAR1LMNAALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148201-A4 | NAPHTALENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMA CEUTICAL USES. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-26 | — | — | EP | disclosed |
| EP-0148201-A1 | NAPHTALENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMA CEUTICAL USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1985-07-17 | — | — | EP | disclosed |
| WO-1984004245-A1 | NAPHTALENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMA CEUTICAL USES | RORER INT OVERSEAS (US) | 1984-11-08 | — | — | WO | disclosed |