Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.54 |
| ▸ | NCEH1 | Q6PIU2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11570035 | 0.86 | SIGMAR1 (0.56) | SIGMAR1NCEH1ALDH1A1HPGDCDC25B | |
| SCHEMBL2090833 | 0.83 | SIGMAR1 (0.59) | SIGMAR1NCEH1LMNA | |
| SCHEMBL2090835 | 0.81 | SIGMAR1 (0.61) | SIGMAR1NCEH1ALDH1A1LMNA | |
| SCHEMBL10960645 | 0.80 | SIGMAR1 (0.49) | SIGMAR1NCEH1ALDH1A1HPGDLMNA | |
| SCHEMBL2091261 | 0.78 | DDB1 (0.40) | ALDH1A1 | |
| SCHEMBL2093891 | 0.78 | CHRNB2 (0.36) | NCEH1ALDH1A1LMNA | |
| SCHEMBL8150820 | 0.77 | SIGMAR1 (0.65) | SIGMAR1 | |
| SCHEMBL5923592 | 0.77 | SIGMAR1 (0.56) | SIGMAR1NCEH1LMNA | |
| SCHEMBL6002255 | 0.76 | RXRA (0.39) | SIGMAR1ALDH1A1LMNA | |
| SCHEMBL6002450 | 0.76 | PTGIR (0.39) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |