Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095867 | 0.85 | CNR2 (0.57) | MEN1KMT2AKDM4ERCE1ALDH1A1 | |
| SCHEMBL17479303 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL11376733 | 0.77 | ALDH1A1 (0.77) | MEN1KMT2AKDM4ERCE1ALDH1A1 | |
| SCHEMBL1095594 | 0.76 | ALDH1A1 (0.55) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL15276776 | 0.75 | MEN1 (0.77) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL23711000 | 0.75 | MAPT (0.59) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL24337259 | 0.75 | MAPT (0.70) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8290348 | 0.74 | MAPT (0.75) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL15276800 | 0.74 | SMN1; SMN2 (0.71) | MEN1KMT2AALDH1A1MAPTUSP2 | |
| SCHEMBL1001675 | 0.73 | L3MBTL1 (0.83) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153803-B2 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090259044-A1 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2009-10-15 | — | — | US | disclosed |
| EP-2068875-A2 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | The General Hospital Corporation (US) | 2009-06-17 | — | — | EP | disclosed |
| US-20090069559-A1 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION | 2009-03-12 | — | — | US | disclosed |
| US-20090069559-A1 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION | 2009-03-12 | — | — | US | disclosed |
| WO-2008011476-A2 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021063-A1 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069559-A1 | Compositions and methods for modulating sirtuin activity | SIRT2, SIRT1, SIRT3 | MEN1 2753/4885KMT2A 261/4885KDM4E 957/4885 |
| US-20090259044-A1 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | SIRT2, SIRT1, SIRT3 | MEN1 2753/4885KMT2A 261/4885KDM4E 957/4885 |
| US-20080021063-A1 | Compositions and methods for modulating sirtuin activity | SIRT2, SIRT1, SIRT3 | MEN1 2753/4885KMT2A 261/4885KDM4E 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.