SCHEMBL109657

SCHEMBL109657

NNC(=O)c1ccccn1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.61
HDAC4 P56524 1/20 0.61
HDAC1 Q13547 1/20 0.61
HDAC7 Q8WUI4 1/20 0.61
HDAC2 Q92769 1/20 0.61
HDAC10 Q969S8 1/20 0.61
HDAC11 Q96DB2 1/20 0.61
HDAC8 Q9BY41 1/20 0.61
HDAC6 Q9UBN7 1/20 0.61
HDAC9 Q9UKV0 1/20 0.61
HDAC5 Q9UQL6 1/20 0.61
CES2 O00748 1/20 0.59
CES1 P23141 1/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
KMT2A Q03164 2/20 0.59
P2RX7 Q99572 3/20 0.58
LMNA P02545 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
NAPRT Q6XQN6 1/20 0.57
P4HTM Q9NXG6 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28131851 1.00 HDAC3 (0.61) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL17500942 0.98 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL8939068 0.98 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Bromide SCHEMBL27617389 0.98 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Methylene Chloride SCHEMBL28230710 0.96 HDAC3 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
Trifluoroacetic Acid SCHEMBL27673946 0.88 KMT2A (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL29136571 0.83 TLR7 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4508472 0.83 CES2 (0.64) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1147702 0.83 KDM4E (0.73) CES2CES1SMN1; SMN2LMNAL3MBTL1
SCHEMBL28218344 0.82 KMT2A (0.63) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 843 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120064228-A On-site visual fluorescence detection reagent for synthesizing cannabinoid-MDMB 中国科学院新疆理化技术研究所 2025-05-30 CN claimed
CN-119731183-A Solid forms of macrocyclic compounds as CFTR modulators and their preparation 弗特克斯药品有限公司 2025-03-28 CN claimed
WO-2025020685-A1 PEROVSKITE THIN FILM LAYER AND PREPARATION METHOD THEREFOR, AND PEROVSKITE SILICON STACKED SOLAR CELL AND PREPARATION METHOD THEREFOR 通威太阳能(成都)有限公司 2025-01-30 WO claimed
US-20240335420-A1 N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV 1.7 AND/OR NAV 1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME AND KITS EUROFARMA LABORATÓRIOS S.A. (BR) 2024-10-10 US claimed
CN-118420524-A Pyridine hydrazide tripodia functionalized fluorescent sensor and synthesis and application thereof in detection of zinc ions 西北民族大学 2024-08-02 CN claimed
EP-4382101-A1 N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS Eurofarma Laboratórios S.A. (BR) 2024-06-12 EP claimed
CN-117720925-A Groove buffer etching solution for inhibiting titanium nitride corrosion 湖北兴福电子材料股份有限公司 2024-03-19 CN claimed
CN-113527196-B Be used for detecting Al 3+ And Zn 2+ Compounds of (C), preparation method and application thereof 南京林业大学 2023-12-22 CN claimed
CN-116887609-A Perovskite thin film layer and preparation method thereof, perovskite silicon laminated solar cell and preparation method thereof 通威太阳能(成都)有限公司 2023-10-13 CN claimed
CN-116410441-A Water-based polyurethane-acrylate emulsion and preparation method thereof 万华化学集团股份有限公司 2023-07-11 CN claimed
CN-102712638-A New phenylhydrazone derivatives and their use as pharmaceuticals ARTERIA CORP 2012-10-03 CN claimed
CN-100453541-C Substituted oxdiazole or triazole thioketone compounds, preparation and application thereof SHENYANG RES INST CHEMICAL IND (CN) 2009-01-21 CN claimed
CN-1927859-A Substituted oxdiazole or triazole thioketone compounds, preparation and application thereof SHENYANG RES INST CHEMICAL IND (CN) 2007-03-14 CN claimed
EP-1448553-B1 N-HETEROCYCLYL HYDRAZIDES AS NEUROTROPHIC AGENTS ORTHO MCNEIL PHARM INC (US) 2005-05-04 EP claimed
EP-1448553-A1 N-HETEROCYCLYL HYDRAZIDES AS NEUROTROPHIC AGENTS Ortho McNeil Pharmaceutical, Inc. (US) 2004-08-25 EP claimed
US-20030144262-A1 N-heterocyclyl hydrazides as neurotrophic agents ORTHO-MCNEIL PHARMACEUTICAL, INC. 2003-07-31 US claimed
WO-2003029247-A1 N-HETEROCYCLYL HYDRAZIDES AS NEUROTROPHIC AGENTS ORTHO MC NEIL PHARMACEUTICAL, INC. (US) 2003-04-10 WO claimed
EP-0323590-A2 Carbazoyl derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1989-07-12 EP claimed
EP-0214158-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1987-03-18 EP claimed
WO-1986004582-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1986-08-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240335420-A1 N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV 1.7 AND/OR NAV 1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME AND KITS SCN1A, SCN1B, CACNA1B HDAC3 141/4885HDAC4 448/4885HDAC1 120/4885
US-20030144262-A1 N-heterocyclyl hydrazides as neurotrophic agents BDNF, NGF, GAP43 HDAC3 2460/4885HDAC4 910/4885HDAC1 730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.