Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963204 | 0.83 | MAPT (0.47) | MAPTNPC1RAB9APKMMEN1 | |
| SCHEMBL11010897 | 0.82 | MAPT (0.47) | MAPTNPC1RAB9ARORCPKM | |
| SCHEMBL10964529 | 0.81 | RAB9A (0.57) | MAPTMAPK1NPC1RAB9ARORC | |
| SCHEMBL10962775 | 0.80 | MAPT (0.46) | MAPTNPC1RAB9ARORCPKM | |
| Lotifazole SCHEMBL286772 | 0.80 | ELOVL1 (0.56) | MAPTMAPK1NPC1RAB9APKM | |
| SCHEMBL10968375 | 0.80 | MAPK1 (0.52) | MAPTMAPK1NPC1RAB9ARORC | |
| SCHEMBL10964867 | 0.79 | HDAC3 (0.58) | MAPTMAPK1NPC1RAB9AMEN1 | |
| SCHEMBL11241744 | 0.75 | ROCK1 (0.54) | MAPTMEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL11322732 | 0.74 | ABL1 (0.61) | MAPTMAPK1NPC1RAB9ARORC | |
| SCHEMBL3188023 | 0.74 | ATAD2 (0.51) | MAPTMAPK1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068033-B1 | N-(4-PHENYL-2-THIAZOLYL)CARBAMATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1985-07-10 | — | — | EP | disclosed |
| US-4511574-A | IMMUNOMODULATORS | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1985-04-16 | — | — | US | disclosed |
| EP-0068033-A1 | N-(4-PHENYL-2-THIAZOLYL)CARBAMATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1983-01-05 | — | — | EP | disclosed |