Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972861 | 0.87 | DRD4 (0.44) | DRD4TRPV1POLBDRD2OPRL1 | |
| Hydrochloric Acid SCHEMBL10971146 | 0.85 | CCR5 (0.46) | DRD4DRD2DRD3KMT2ASMN1; SMN2 | |
| SCHEMBL11256028 | 0.84 | DRD4 (0.43) | DRD4TRPV1KMT2AOPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL10970472 | 0.83 | DRD2 (0.48) | DRD4POLBDRD2DRD3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10973696 | 0.79 | NPC1 (0.47) | DRD2KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL11265638 | 0.78 | FABP6 (0.44) | DRD4OPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL10969111 | 0.76 | DRD2 (0.46) | DRD4POLBDRD2DRD3KMT2A | |
| Hydrochloric Acid SCHEMBL10972048 | 0.75 | KDM4E (0.47) | DRD2KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11177227 | 0.73 | SMN1; SMN2 (0.52) | DRD4DRD2DRD3SMN1; SMN2 | |
| SCHEMBL10967335 | 0.73 | KDM4E (0.48) | DRD4DRD2DRD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064706-B1 | 5-(4-PHENYL-1-PIPERIDINYL)METHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| EP-0064706-A1 | 5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329470-A | CORDIOTONIC, HYPOTENSIVE, ANTITHROMBOSIS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |