Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921310 | 0.83 | FABP6 (0.48) | FABP6PDE3BPDE3APDE4APDE4B | |
| SCHEMBL11256028 | 0.80 | DRD4 (0.43) | OPRL1KCNH2DRD4 | |
| SCHEMBL10972861 | 0.79 | DRD4 (0.44) | OPRL1KCNH2DRD4 | |
| SCHEMBL10969661 | 0.78 | DRD4 (0.50) | OPRL1KCNH2DRD4 | |
| Hydrochloric Acid SCHEMBL10915699 | 0.75 | SIGMAR1 (0.49) | DRD4CCR5GAASIGMAR1 | |
| Hydrochloric Acid SCHEMBL10917762 | 0.75 | PDE3B (0.51) | PDE3BPDE3ACCR5PDE4APDE4B | |
| SCHEMBL7434193 | 0.73 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10914304 | 0.72 | ACHE (0.44) | DRD4CHRM2SIGMAR1 | |
| SCHEMBL10915707 | 0.71 | MEN1 (0.51) | KCNH2CCR5CHRM2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10921255 | 0.71 | PDE3B (0.52) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-A1 | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329471-A | CARDIOTONICS, HYPOTENSIVE AGENTS, AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |