Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256028 | 0.87 | DRD4 (0.43) | DRD4BRD4OPRL1KCNH2TRPV1 | |
| SCHEMBL10969661 | 0.87 | DRD4 (0.50) | DRD4POLBOPRL1KCNH2TRPV1 | |
| SCHEMBL11265638 | 0.79 | FABP6 (0.44) | DRD4OPRL1KCNH2 | |
| SCHEMBL10971590 | 0.76 | POLB (0.45) | POLBKCNH2ALDH1A1ABL1RIN1 | |
| Hydrochloric Acid SCHEMBL10972048 | 0.74 | KDM4E (0.47) | HDAC1DRD2ALDH1A1PARP1 | |
| SCHEMBL10970591 | 0.72 | ALDH1A1 (0.47) | POLBDRD2ALDH1A1ABL1RIN1 | |
| SCHEMBL10967335 | 0.72 | KDM4E (0.48) | DRD4DRD2ALDH1A1PARP1 | |
| Hydrochloric Acid SCHEMBL10967357 | 0.72 | ALDH1A1 (0.47) | POLBDRD2ALDH1A1ABL1RIN1 | |
| Hydrochloric Acid SCHEMBL10970332 | 0.72 | LIPG (0.45) | DRD2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10970472 | 0.71 | DRD2 (0.48) | DRD4POLBDRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064706-B1 | 5-(4-PHENYL-1-PIPERIDINYL)METHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| EP-0064706-A1 | 5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329470-A | CORDIOTONIC, HYPOTENSIVE, ANTITHROMBOSIS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |