Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977269 | 1.00 | ADRB2 (0.48) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL3766310 | 0.83 | ADRB2 (0.71) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL3766308 | 0.83 | ADRB2 (0.71) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL10979424 | 0.80 | ALDH1A1 (0.43) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL10979422 | 0.80 | ALDH1A1 (0.43) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL11289301 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1PKMKDM4EHPGD | |
| SCHEMBL1402286 | 0.75 | ALDH1A1 (0.49) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL10974237 | 0.72 | INSR (0.46) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL10974234 | 0.72 | INSR (0.46) | ADRB2SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL316151 | 0.71 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1PKMKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0050558-B1 | PHOTOGRAPHIC EMULSIONS AND ELEMENTS CAPABLE OF FORMING DIRECT-POSITIVE IMAGES | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-07-17 | — | — | EP | disclosed |
| US-4306016-A | HETEROCYCLIC CYANINE DYE-LIKE NUCLEATING AGENTS | EASTMAN KODAK COMPANY (US) | 1981-12-15 | — | — | US | disclosed |