Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982627 | 0.89 | BRD4 (0.43) | KMT2A | |
| SCHEMBL10981870 | 0.88 | GAA (0.47) | POLBKMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10983498 | 0.87 | GAA (0.47) | POLBKMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10981561 | 0.85 | TLR9 (0.36) | POLBKMT2AKDM4ELMNAHTT | |
| SCHEMBL10984221 | 0.85 | NPC1 (0.39) | NPC1RAB9A | |
| SCHEMBL11079151 | 0.83 | NPC1 (0.40) | POLBKMT2ANPC1RAB9A | |
| SCHEMBL10977643 | 0.83 | NPC1 (0.38) | NPC1RAB9A | |
| SCHEMBL10979812 | 0.80 | GAA (0.46) | POLBKMT2AKDM4ELMNAHTT | |
| SCHEMBL11197697 | 0.80 | KMT2A (0.43) | POLBKMT2AKDM4ELMNAHTT | |
| SCHEMBL11086175 | 0.79 | GABRA1 (0.39) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499279-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4397850-A | HYPOGLYCEMIC, ANTIDIABETIC | SANDOZ, INC. (US) | 1983-08-09 | — | — | US | disclosed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |