Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080541 | 0.89 | BRD4 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10832655 | 0.87 | KMT2A (0.40) | NPC1RAB9A | |
| SCHEMBL11079151 | 0.86 | NPC1 (0.40) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10977643 | 0.85 | NPC1 (0.38) | NPC1RAB9A | |
| SCHEMBL10831709 | 0.84 | MAPT (0.43) | PADI4BRD4 | |
| SCHEMBL10984221 | 0.83 | NPC1 (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11089655 | 0.80 | TLR9 (0.37) | TLR9TLR8TLR7BRD4 | |
| SCHEMBL10977892 | 0.79 | POLB (0.43) | NPC1RAB9A | |
| SCHEMBL10831731 | 0.78 | TLR8 (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10832301 | 0.77 | EGFR (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4467096-A | ANTIDIABETIC AGENTS, INTERMEDIATES THEREFOR | SANDOZ, INC. (US) | 1984-08-21 | — | — | US | disclosed |
| US-4421752-A | ANTIDIABETIC AGENT | SANDOZ, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| US-4336391-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |