Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721149 | 0.80 | ADRA2A (0.43) | ALDH1A1GAAMAPTTHRB | |
| SCHEMBL8020018 | 0.68 | ADRA2B (0.41) | MEN1ALDH1A1MAPTKMT2A | |
| Bromide SCHEMBL7086983 | 0.61 | — | — | |
| SCHEMBL14878894 | 0.60 | ALDH1A1 (0.43) | MEN1ALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL10979251 | 0.60 | HTR1D (0.71) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10973842 | 0.59 | HTR1D (0.69) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10619129 | 0.59 | ALDH1A1 (0.41) | MEN1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL112391 | 0.59 | ALDH1A1 (0.53) | MEN1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL10883487 | 0.58 | POLB (0.57) | ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL322046 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558063-A | INHIBIT SMALL INTESTINE SECRETION | BEECHAM GROUP P.L.C. (GB) | 1985-12-10 | — | — | US | disclosed |
| EP-0043659-B1 | CLONIDINE DERIVATIVES USEFUL IN THE TREATMENT OF DIARRHOEA | BEECHAM GROUP PLC (GB) | 1985-02-06 | — | — | EP | disclosed |
| US-4450170-A | A P-AMINO CLONIDINE ALONG WITH AN ORAL HYDRATION AGENT; ANTISECRETORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1984-05-22 | — | — | US | disclosed |
| EP-0043659-A1 | Clonidine derivatives useful in the treatment of diarrhoea | BEECHAM GROUP PLC (GB) | 1982-01-13 | — | — | EP | disclosed |