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Sugi Predict / Compounds / SCHEMBL1098475

SCHEMBL1098475

SCHEMBL1098475

Cc1c(N(CCCCC(F)(F)F)S(=O)(=O)c2ccc(N3CCOCC3)cc2)sc2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 6/20 0.43
▸ RORC P51449 1/20 0.39
▸ HTR1A P08908 2/20 0.37
▸ DRD2 P14416 2/20 0.37
▸ HTR2A P28223 2/20 0.37
▸ HTR7 P34969 2/20 0.37
▸ HTR6 P50406 2/20 0.37
▸ TSHR P16473 2/20 0.37
▸ PKM P14618 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ GAA P10253 1/20 0.35
▸ CNR2 P34972 1/20 0.35
▸ CASP3 P42574 2/20 0.34
▸ PHOSPHO1 Q8TCT1 1/20 0.34
▸ MAPT P10636 4/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1098906 0.92 TRPM8 (0.44) TRPM8HTR1ADRD2HTR2AHTR7
SCHEMBL1099282 0.91 TRPM8 (0.43) TRPM8RORCHTR1ADRD2HTR2A
SCHEMBL1098856 0.85 TRPM8 (0.51) TRPM8RORCHTR1ADRD2HTR2A
SCHEMBL1100358 0.85 TRPM8 (0.41) TRPM8RORCHTR1AHTR2AHTR7
SCHEMBL1099543 0.83 LMNA (0.34) TRPM8HTR1ADRD2HTR2AHTR7
SCHEMBL1100541 0.82 TRPM8 (0.47) TRPM8RORCHTR1ADRD2HTR2A
SCHEMBL1099774 0.82 TRPM8 (0.52) TRPM8RORCHTR1ADRD2HTR2A
SCHEMBL1099477 0.81 TRPM8 (0.64) TRPM8
SCHEMBL1107227 0.81 TRPM8 (0.46) TRPM8RORC
SCHEMBL1098983 0.80 RORC (0.41) RORCHTR1ADRD2HTR2AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9434711-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, N.V. (BE) 2016-09-06 — — US disclosed
US-20140315899-A1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-10-23 — — US disclosed
US-8809327-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2014-08-19 — — US disclosed
EP-2183239-B1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2012-08-22 — — EP disclosed
US-20120190674-A1 SULFONAMIDES AS TRPM8 MODULATORS BRANUM SHAWN T (US) 2012-07-26 — — US disclosed
US-8153682-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2012-04-10 — — US disclosed
US-20090264474-A1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2009-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190674-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885RORC 3514/4885HTR1A 432/4885
US-20140315899-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885RORC 3514/4885HTR1A 432/4885
US-20090264474-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885RORC 3514/4885HTR1A 432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.