Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 14/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10999352 | 0.89 | ACE (0.52) | ACEKMT2AFFAR2LMNA | |
| SCHEMBL11191864 | 0.87 | ACE (0.53) | ACEFFAR2LMNA | |
| SCHEMBL10995341 | 0.81 | ACE (0.44) | ACEFFAR2LMNA | |
| SCHEMBL10944250 | 0.80 | ACE (0.53) | ACEFFAR2LMNA | |
| SCHEMBL11110326 | 0.80 | ACE (0.51) | ACEKMT2AFFAR2LMNA | |
| SCHEMBL10938815 | 0.79 | ACE (0.71) | ACEKMT2AFFAR2LMNA | |
| SCHEMBL11066115 | 0.79 | ACE (0.71) | ACEKMT2AFFAR2LMNA | |
| SCHEMBL10995336 | 0.78 | FFAR2 (0.43) | ACEFFAR2LMNA | |
| SCHEMBL11195287 | 0.78 | ACE (0.52) | ACEKMT2AFFAR2LMNA | |
| SCHEMBL11061437 | 0.76 | KMT2A (0.58) | ACEKMT2AFFAR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4496578-A | Antihypertensive sulfur-containing compounds | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-01-29 | — | — | US | disclosed |
| US-4483861-A | Antihypertensive sulfur-containing compounds | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-11-20 | — | — | US | disclosed |