Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM3B | Q7LBC6 | 4/20 | 0.35 |
| ▸ | KDM6B | O15054 | 4/20 | 0.35 |
| ▸ | KDM4A | O75164 | 4/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.35 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5901923 | 0.87 | GAA (0.49) | GAAHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL5901422 | 0.84 | ALDH1A1 (0.36) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL9477815 | 0.76 | PDE3B (0.50) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL10994005 | 0.76 | KDM4E (0.42) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL10681150 | 0.76 | UCHL1 (0.50) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL10684520 | 0.75 | UCHL1 (0.46) | KDM4EGAAHSD17B10HPGDLMNA | |
| SCHEMBL10681743 | 0.75 | PDE3B (0.53) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL10675813 | 0.74 | NAPRT (0.43) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL10683554 | 0.74 | UCHL1 (0.43) | KDM4EGAAHSD17B10HPGDALDH1A1 | |
| SCHEMBL13456583 | 0.73 | HSP90AB1 (0.47) | KDM4EHSD17B10ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4524149-A | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4412077-A | Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone | STERLING DRUG INC. (US) | 1983-10-25 | — | — | US | disclosed |
| EP-0089022-A2 | Alkanoylpyridinones useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1983-09-21 | — | — | EP | disclosed |