SCHEMBL11001236

SCHEMBL11001236

CCCNc1cccc(OC)n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.48
CHRNB2 P17787 3/20 0.44
CHRNB4 P30926 3/20 0.44
CHRNA3 P32297 3/20 0.44
CHRNA4 P43681 3/20 0.44
TSPO P30536 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
OPRM1 P35372 1/20 0.41
HDAC1 Q13547 1/20 0.41
ALDH1A1 P00352 1/20 0.41
BLM P54132 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
KDR P35968 1/20 0.41
MAPK8 P45983 1/20 0.41
TAAR1 Q96RJ0 1/20 0.40
FYN P06241 1/20 0.38
TRPV4 Q9HBA0 1/20 0.37
ITGB1 P05556 1/20 0.37
ITGA4 P13612 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8348068 0.85 GRM5 (0.50) GRM5TSPOCYP1A2CYP2C19OPRM1
SCHEMBL21894334 0.84 CYP1A2 (0.47) GRM5TSPOCYP1A2CYP2C19OPRM1
SCHEMBL17364403 0.82 CHRNB2 (0.51) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL11185939 0.81 CYP2C19 (0.53) GRM5TSPOCYP1A2CYP2C19OPRM1
SCHEMBL12933379 0.79 NUDT1 (0.47) GRM5TSPOCYP1A2CYP2C19OPRM1
SCHEMBL17364384 0.79 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4CYP1A2
SCHEMBL12893079 0.78 CHRNB2 (0.43) GRM5CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL15353282 0.77 TSPO (0.49) GRM5TSPOCYP1A2CYP2C19OPRM1
SCHEMBL18809821 0.76 HDAC1 (0.57) CYP1A2CYP2C19HDAC1ALDH1A1KDR
SCHEMBL6642582 0.76 HDAC1 (0.43) GRM5TSPOCYP1A2CYP2C19OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4560762-A HERBICIDE INTERMEDIATES TOYO SODA MANUFACTURING CO. LTD. (JP) 1985-12-24 US claimed
US-7868204-B2 Inhibitors of histone deacetylase METHYLGENE INC. (CA) 2011-01-11 US disclosed
US-7838520-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2010-11-23 US disclosed
US-7595343-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2009-09-29 US disclosed
CN-85108132-A Compounds process for production thereof 1986-07-16 CN disclosed