Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TCF4 | P15884 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11510618 | 0.91 | ALDH1A1 (0.43) | GAAALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL11510885 | 0.84 | MAPT (0.43) | GAALMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL10996368 | 0.83 | GAA (0.43) | GAALMNAALDH1A1MAPTHPGD | |
| SCHEMBL10996371 | 0.83 | GAA (0.43) | GAALMNAALDH1A1MAPTHPGD | |
| SCHEMBL10998937 | 0.82 | GAA (0.41) | GAALMNAALDH1A1MAPTHPGD | |
| SCHEMBL11512796 | 0.81 | ALDH1A1 (0.49) | GAALMNAALDH1A1MAPTHPGD | |
| SCHEMBL572903 | 0.78 | KDM4E (0.38) | GAALMNAALDH1A1MAPTHPGD | |
| SCHEMBL572902 | 0.78 | KDM4E (0.38) | GAALMNAALDH1A1MAPTHPGD | |
| SCHEMBL574218 | 0.76 | HPGD (0.45) | GAAALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL574219 | 0.76 | HPGD (0.45) | GAAALDH1A1MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4492710-A | Substituted pyrrolidinyl-benzoic acid derivatives and a process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-01-08 | — | — | US | disclosed |
| US-4172142-A | DIURETICS FOR TREATMENT OF EDEMA | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-10-23 | — | — | US | disclosed |