SCHEMBL11007296

SCHEMBL11007296

CC(C)(C(=O)C(Br)Oc1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.46
MAPT P10636 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.38
ATM Q13315 1/20 0.38
MTNR1A P48039 1/20 0.37
MTNR1B P49286 1/20 0.37
CYP2C19 P33261 2/20 0.37
KCNN4 O15554 1/20 0.37
HIF1A Q16665 1/20 0.37
CYP1A2 P05177 2/20 0.37
GAA P10253 2/20 0.37
CYP2C9 P11712 1/20 0.37
PKM P14618 1/20 0.37
ALDH1A1 P00352 3/20 0.36
ALOX15 P16050 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11006062 0.91 PPARG (0.42) KMT2AMAPTL3MBTL1CYP2C19CYP1A2
SCHEMBL11002653 0.90 PPARG (0.43) KMT2AMAPTCYP2C19CYP1A2MEN1
SCHEMBL11001230 0.90 PPARA (0.43) KMT2AMAPTCYP2C19CYP1A2MEN1
SCHEMBL11003980 0.87 OGG1 (0.44) KMT2AMAPTL3MBTL1PKMALDH1A1
SCHEMBL11005429 0.87 HDAC3 (0.43) KMT2AMAPTL3MBTL1ATMMTNR1A
SCHEMBL11004596 0.86 PKM (0.41) KMT2AMAPTL3MBTL1PKMALDH1A1
SCHEMBL11300616 0.84 L3MBTL1 (0.41) KMT2AMAPTL3MBTL1ATMMTNR1A
SCHEMBL11005515 0.82 PPARA (0.48) KMT2AMAPTCYP2C19CYP1A2GAA
SCHEMBL11003522 0.81 PPARA (0.42) KMT2AMAPTCYP2C19CYP1A2GAA
SCHEMBL11005358 0.80 ALDH1A1 (0.43) KMT2AMAPTGAAALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0150499-A2 Substituted 3-azolyl butane derivatives, process for their preparation and agricultural and horticultural fungicides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1985-08-07 EP disclosed