Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 6/20 | 0.38 |
| ▸ | FCER2 | P06734 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11014003 | 0.81 | REN (0.47) | ACERENMMECPA1ACE2 | |
| SCHEMBL16359592 | 0.81 | ACE (0.39) | ACEMMP1FCER2MMECPA1 | |
| SCHEMBL11009837 | 0.79 | ACE (0.34) | ACEMMP1RENCDK4CCNA2 | |
| SCHEMBL13363654 | 0.79 | ACE (0.49) | ACERENMMECPA1ACE2 | |
| SCHEMBL31020879 | 0.79 | ACE (0.38) | ACEMMP1RENFCER2ERAP2 | |
| SCHEMBL11014616 | 0.78 | F2 (0.35) | ACEREN | |
| SCHEMBL10506297 | 0.78 | ACE (0.40) | ACEMMECPA1ACE2ECE1 | |
| SCHEMBL10687094 | 0.78 | ACE (0.40) | ACEMMECPA1ACE2ECE1 | |
| SCHEMBL10687059 | 0.78 | ACE (0.40) | ACEMMECPA1ACE2ECE1 | |
| SCHEMBL10431137 | 0.78 | ACE (0.39) | ACEMMP1RENFCER2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0143746-A2 | 5-Amino 4-hydroxy-valeryl-substituted derivatives | CIBA-GEIGY AG (CH) | 1985-06-05 | — | — | EP | disclosed |