Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11325593 | 0.98 | ALDH1A1 (0.41) | ALDH1A1MAPTRAB9AKDM4EMEN1 | |
| SCHEMBL11326258 | 0.95 | ALDH1A1 (0.37) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL10887538 | 0.82 | MAPT (0.38) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL7186350 | 0.74 | ALDH1A1 (0.41) | ALDH1A1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL9457581 | 0.74 | KCNH2 (0.45) | ALDH1A1MAPTRAB9AKDM4EMEN1 | |
| SCHEMBL27913052 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL16498140 | 0.71 | ALDH1A1 (0.44) | ALDH1A1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL11338473 | 0.71 | GABRP (0.45) | ALDH1A1MAPTDHFRGABRPGABRD | |
| SCHEMBL27892818 | 0.70 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL27912797 | 0.70 | ALDH1A1 (0.33) | ALDH1A1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170290814-A1 | METHODS OF TREATMENT OF CHOLESTASIS AND FIBROSIS | GENFIT (FR) | 2017-10-12 | — | — | US | disclosed |
| US-8940894-B2 | Aminothiazole compounds as kinase inhibitors and methods of using the same | AB SCIENCE (FR) | 2015-01-27 | — | — | US | disclosed |
| US-20130289045-A1 | AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USING THE SAME | AB SCIENCE (FR) | 2013-10-31 | — | — | US | disclosed |
| US-8492545-B2 | Aminothiazole compounds as kinase inhibitors and methods of using the same | AB SCIENCE (FR) | 2013-07-23 | — | — | US | disclosed |
| US-20120196871-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2012-08-02 | — | — | US | disclosed |
| US-8153792-B2 | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors | AB SCIENCE (FR) | 2012-04-10 | — | — | US | disclosed |
| EP-2366703-A1 | Polymorph form of 2-amino (nitroaryl) thiazole derivative | AB Science (FR) | 2011-09-21 | — | — | EP | disclosed |
| EP-2118099-B1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2011-07-06 | — | — | EP | disclosed |
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2010-05-13 | — | — | US | disclosed |
| EP-2118099-A2 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB Science (FR) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098949-A2 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | ABL1, ABL2, KIT | ALDH1A1 638/4885MAPT 3714/4885RAB9A 1467/4885 |
| US-20170290814-A1 | METHODS OF TREATMENT OF CHOLESTASIS AND FIBROSIS | NR1H4, SLC10A1, MMP1 | ALDH1A1 748/4885MAPT 4417/4885RAB9A 3681/4885 |
| US-20120196871-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | ABL1, ABL2, ALK | ALDH1A1 811/4885MAPT 3774/4885RAB9A 1534/4885 |
| US-20130289045-A1 | AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USING THE SAME | ABL1, ABL2, ALK | ALDH1A1 813/4885MAPT 3602/4885RAB9A 1400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.