SCHEMBL7186350

SCHEMBL7186350

CCCCCc1nc(N)sc1C=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 1/20 0.36
RAB9A P51151 1/20 0.36
CXCR1 P25024 1/20 0.33
CXCR2 P25025 1/20 0.33
DHFR P00374 1/20 0.33
GABRP O00591 1/20 0.33
GABRD O14764 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB1 P18505 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33
GABRB2 P47870 1/20 0.33
GABRA4 P48169 1/20 0.33
GABRE P78334 1/20 0.33
GABRA6 Q16445 1/20 0.33
GABRG1 Q8N1C3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1101351 0.74 ALDH1A1 (0.39) ALDH1A1KDM4ERAB9ACXCR1CXCR2
SCHEMBL16498140 0.74 ALDH1A1 (0.44) ALDH1A1KDM4ERAB9ACXCR1CXCR2
SCHEMBL11338473 0.73 GABRP (0.45) ALDH1A1DHFRGABRPGABRDGABRA1
SCHEMBL11325593 0.73 ALDH1A1 (0.41) ALDH1A1KDM4ERAB9ACXCR1CXCR2
SCHEMBL28776677 0.72 KDM4E (0.42) ALDH1A1KDM4ERAB9AMEN1KMT2A
SCHEMBL19936638 0.70 AGER (0.43) ALDH1A1KDM4ERAB9AMEN1KMT2A
SCHEMBL10358696 0.70 ALDH1A1 (0.41) ALDH1A1KDM4ERAB9ACXCR2DHFR
SCHEMBL10358694 0.69 ALDH1A1 (0.40) ALDH1A1KDM4ERAB9ADHFRGABRP
SCHEMBL5596147 0.69 TLR8 (0.41) ALDH1A1KDM4ERAB9ACXCR2DHFR
SCHEMBL11326258 0.69 ALDH1A1 (0.37) ALDH1A1RAB9AGABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6528223-B1 Particle composition comprising binder polymer and specified dye having various substituents introduced into aromatic ring at thiazolyl 4-position, to avoid tendency toward dye crystallization NEXPRESS SOLUTIONS LLC 2003-03-04 US disclosed