Kuromanin

Kuromanin

SCHEMBL1101355

OC[C@H]1OC(Oc2cc3c(O)cc(O)cc3[o+]c2-c2ccc(O)c(O)c2)[C@@H](O)[C@@H]1O.OC[C@H]1OC(Oc2cc3c(O)cc(O)cc3[o+]c2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD38 P28907 2/20 1.00
DPP4 P27487 2/20 1.00
F2 P00734 2/20 0.89
KDM4E B2RXH2 4/20 0.52
GAA P10253 4/20 0.52
AKR1B1 P15121 4/20 0.52
MAPT P10636 3/20 0.52
POLB P06746 2/20 0.52
P4HB P07237 2/20 0.52
EPHX2 P34913 2/20 0.52
ADRA2C P18825 1/20 0.52
NOX4 Q9NPH5 1/20 0.52
CA12 O43570 1/20 0.52
KDM1A O60341 1/20 0.52
SLCO2B1 O94956 1/20 0.52
CA2 P00918 1/20 0.52
ALPL P05186 1/20 0.52
HMGB1 P09429 1/20 0.52
ALPI P09923 1/20 0.52
PKM P14618 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Kuromanin SCHEMBL9234361 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL30548128 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL29349861 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL8818180 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL289710 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL409593 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL1097555 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL288591 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL1096430 1.00 CD38 (1.00) CD38DPP4F2KDM4EGAA
Kuromanin SCHEMBL440823 0.99 DPP4 (0.98) CD38DPP4F2KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2838379-A2 COMPOSITIONS COMPRISING A COMBINATION OF AT LEAST ONE COLORANT AND AT LEAST ONE POLYSACCHARIDE E.P.C. (Beijing) Plant Pharmaceutical Technology Co. Ltd. (CN) 2015-02-25 EP disclosed
US-20140364512-A9 COMPOSITIONS COMPRISING A COMBINATION OF AT LEAST ONE COLORANT AND AT LEAST ONE POLYSACCHARIDE EPC (BEIJING) NATURAL PRODUCTS CO., LTD. (CN) 2014-12-11 US disclosed
US-20140178508-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (DE) 2014-06-26 US disclosed
US-8623429-B2 Stabilized anthocyanin compositions OMNICA GMBH (DE) 2014-01-07 US disclosed
US-20130281548-A1 COMPOSITIONS COMPRISING A COMBINATION OF AT LEAST ONE COLORANT AND AT LEAST ONE POLYSACCHARIDE EPC (BEIJING) NATURAL PRODUCTS CO., LTD. (CN) 2013-10-24 US disclosed
WO-2013156863-A2 COMPOSITIONS COMPRISING A COMBINATION OF AT LEAST ONE COLORANT AND AT LEAST ONE POLYSACCHARIDE E.P.C. (BEIJING) PLANT PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2013-10-24 WO disclosed
US-20130210908-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (DE) 2013-08-15 US disclosed
US-8449927-B2 Stabilized anthocyanin compositions OMNICA GMBH (DE) 2013-05-28 US disclosed
US-20120328755-A2 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (DE) 2012-12-27 US disclosed
US-20120277173-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH 2012-11-01 US disclosed
US-20110217418-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH 2011-09-08 US disclosed
US-20110217286-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH 2011-09-08 US disclosed
US-20110117221-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH 2011-05-19 US disclosed
US-7820207-B2 Stabilized anthocyanin compositions OMNICA GMBH (DE) 2010-10-26 US disclosed
EP-2124637-A2 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (DE) 2009-12-02 EP disclosed
US-20090181901-A1 COMPOSITIONS AND METHODS TO INCREASE BIOAVAILABILITY OF CAROTENOIDS OMNICA GMBH (DE) 2009-07-16 US disclosed
WO-2009063333-A2 COMPOSITIONS AND METHODS TO INCREASE BIOAVAILABILITY OF CAROTENOIDS OMNICA GMBH (US) 2009-05-22 WO disclosed
WO-2009031051-A9 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (DE) 2009-05-07 WO disclosed
WO-2009031051-A2 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (US) 2009-03-12 WO disclosed
US-20080255226-A1 STABILIZED ANTHOCYANIN COMPOSITIONS OMNICA GMBH (DE) 2008-10-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181901-A1 COMPOSITIONS AND METHODS TO INCREASE BIOAVAILABILITY OF CAROTENOIDS SLC19A1, RBP4, CYP8B1 CD38 1289/4885DPP4 984/4885F2 922/4885
US-20140178508-A1 STABILIZED ANTHOCYANIN COMPOSITIONS NQO1, CRY2, GANC CD38 195/4885DPP4 1564/4885F2 1162/4885
US-20110217286-A1 STABILIZED ANTHOCYANIN COMPOSITIONS NQO1, CRY2, GANC CD38 195/4885DPP4 1564/4885F2 1162/4885
US-20130210908-A1 STABILIZED ANTHOCYANIN COMPOSITIONS NQO1, CRY2, GANC CD38 195/4885DPP4 1564/4885F2 1162/4885
US-20080255226-A1 STABILIZED ANTHOCYANIN COMPOSITIONS NQO1, CRY2, GANC CD38 195/4885DPP4 1564/4885F2 1162/4885
US-20110117221-A1 STABILIZED ANTHOCYANIN COMPOSITIONS NQO1, CRY2, GANC CD38 195/4885DPP4 1564/4885F2 1162/4885
US-20120277173-A1 STABILIZED ANTHOCYANIN COMPOSITIONS NQO1, CRY2, GANC CD38 195/4885DPP4 1564/4885F2 1162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.