Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Kuromanin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.98 |
| ▸ | CD38 | P28907 | 2/20 | 0.98 |
| ▸ | F2 | P00734 | 2/20 | 0.87 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | P4HB | P07237 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kuromanin SCHEMBL29762023 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL29377806 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL316825 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL158216 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL29349461 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL3765133 | 0.99 | DPP4 (0.96) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL625949 | 0.99 | DPP4 (0.96) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL288591 | 0.99 | CD38 (1.00) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL1097555 | 0.99 | CD38 (1.00) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL1096430 | 0.99 | CD38 (1.00) | DPP4CD38F2SNCAGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4489768-A1 | ARONIA EXTRACTS AND USES THEREOF | Diana (FR) | 2025-01-15 | — | — | EP | claimed |
| WO-2023170229-A1 | ARONIA EXTRACTS AND USES THEREOF | DIANA (FR) | 2023-09-14 | — | — | WO | claimed |
| EP-4241780-A1 | ENRICHED POLYPHENOLIC FRACTIONS OF ARONIA EXTRACTS AND USES THEREOF | Diana (FR) | 2023-09-13 | — | — | EP | claimed |
| EP-4241779-A1 | ARONIA EXTRACTS AND USES THEREOF | Diana Food (FR) | 2023-09-13 | — | — | EP | claimed |
| CN-110731982-A | method for preparing Vaccinium myrtillus extract with high anthocyanin content | 惠州市晟荣生物科技有限公司 | 2020-01-31 | — | — | CN | claimed |
| JP-3209320-A | — | — | None | — | — | JP | disclosed |
| EP-4489768-A1 | ARONIA EXTRACTS AND USES THEREOF | Diana (FR) | 2025-01-15 | — | — | EP | disclosed |
| CN-119302420-A | Donkey-hide gelatin composition and preparation method thereof | 广东旗峰健康产业有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-117617502-A | Composition for regulating cornea MMP-9 level and application thereof | 仙乐健康科技股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2023170229-A1 | ARONIA EXTRACTS AND USES THEREOF | DIANA (FR) | 2023-09-14 | — | — | WO | disclosed |
| EP-4241779-A1 | ARONIA EXTRACTS AND USES THEREOF | Diana Food (FR) | 2023-09-13 | — | — | EP | disclosed |
| EP-4241780-A1 | ENRICHED POLYPHENOLIC FRACTIONS OF ARONIA EXTRACTS AND USES THEREOF | Diana (FR) | 2023-09-13 | — | — | EP | disclosed |
| US-8361167-B2 | Natural hair dyes | UNIVERSITY OF LEEDS (GB) | 2013-01-29 | — | — | US | disclosed |
| EP-2477597-A2 | NATURAL HAIR DYES | University Of Leeds (GB) | 2012-07-25 | — | — | EP | disclosed |
| US-20120060303-A1 | NATURAL HAIR DYES | UNIVERSITY OF LEEDS (GB) | 2012-03-15 | — | — | US | disclosed |
| WO-2010131049-A2 | NATURAL HAIR DYES | UNIVERSITY OF LEEDS (GB) | 2010-11-18 | — | — | WO | disclosed |
| EP-2001304-A2 | EXTRACTIONS AND METHODS COMPRISING ELDER SPECIES | Herbalscience Singapore Pte. Ltd. (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070248700-A1 | Extractions and Methods Comprising Elder Species | HERBALSCIENCE NUTRACEUTICALS, LLC | 2007-10-25 | — | — | US | disclosed |
| WO-2007109600-A2 | EXTRACTIONS AND METHODS COMPRISING ELDER SPECIES | HERBALSCIENCE SINGAPORE PTE. LTD. (US) | 2007-09-27 | — | — | WO | disclosed |
| JP-H03209320-A | ANTI-RETROVIRUS AGENT | TORAY IND INC | 1991-09-12 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070248700-A1 | Extractions and Methods Comprising Elder Species | NOP58, MYC, MDM4 | DPP4 53/4885CD38 650/4885F2 819/4885 |
| US-20120060303-A1 | NATURAL HAIR DYES | CYB5R3, GALR3, MC3R | DPP4 4010/4885CD38 478/4885F2 2712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.