Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 2/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 1/20 | 0.31 |
| ▸ | ELOC | Q15369 | 1/20 | 0.31 |
| ▸ | ELOB | Q15370 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8759961 | 0.84 | ESR1 (0.42) | HIF1ACA2PTGS2 | |
| SCHEMBL5236685 | 0.80 | HMOX1 (0.36) | TSHRUSP2 | |
| SCHEMBL1204377 | 0.80 | ALDH1A1 (0.39) | TSHRUSP2 | |
| SCHEMBL9630859 | 0.79 | POLB (0.42) | SMN1; SMN2 | |
| SCHEMBL8704294 | 0.79 | MAOA (0.43) | TSHRUSP2 | |
| SCHEMBL9366681 | 0.78 | NR1I2 (0.42) | USP2PPARGPPARASMN1; SMN2 | |
| SCHEMBL4450540 | 0.77 | SMN1; SMN2 (0.45) | HPGDTSHRLTA4HCA12CA1 | |
| SCHEMBL9050671 | 0.76 | NOS3 (0.37) | NOS3NOS1HPGDTSHRPDCD1 | |
| SCHEMBL1204527 | 0.76 | LOXL2 (0.48) | TSHRSMN1; SMN2 | |
| SCHEMBL11159381 | 0.76 | CYP2A6 (0.38) | HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4530842-A | Containing a cyano substitution in position 3 | SANDOZ LTD. (CH) | 1985-07-23 | — | — | US | disclosed |
| WO-1983004024-A1 | 2(1H)-PYRIDONE DERIVATIVES, PREPARATION THEREOF AND COMPOSITION CONTAINING THEM | SANDOZ AG (CH) | 1983-11-24 | — | — | WO | disclosed |