Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018065 | 0.92 | PDE5A (0.37) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11017158 | 0.89 | PKN1 (0.46) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11022217 | 0.82 | ATR (0.53) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11018557 | 0.82 | PKN1 (0.44) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11021674 | 0.81 | METAP2 (0.46) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11021091 | 0.81 | ATR (0.48) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11017149 | 0.80 | MAPK10 (0.41) | PKN1PKN2CHEK2GSK3BPDE5A | |
| SCHEMBL11021164 | 0.80 | PKN1 (0.42) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL10733507 | 0.80 | PDE5A (0.38) | F2F10PLGPLAUPLAT | |
| SCHEMBL11021240 | 0.79 | MAPT (0.46) | METAP2METAP1PKN1PKN2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |