Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021236 | 0.92 | KDM4E (0.42) | MAPTATRALDH1A1LMNAMEN1 | |
| SCHEMBL11022217 | 0.89 | ATR (0.53) | MAPTATRMETAP2METAP1PKN1 | |
| SCHEMBL11016115 | 0.89 | CFB (0.47) | MAPTATRALDH1A1LMNAMEN1 | |
| SCHEMBL11021091 | 0.88 | ATR (0.48) | MAPTATRALDH1A1LMNAMEN1 | |
| SCHEMBL11021741 | 0.86 | ATR (0.44) | MAPTATRALDH1A1LMNAMEN1 | |
| SCHEMBL11022213 | 0.81 | ATR (0.44) | MAPTATRTRPV4BRPF1 | |
| SCHEMBL11016112 | 0.81 | SCN9A (0.42) | MAPTALDH1A1LMNAMEN1GAA | |
| SCHEMBL11017639 | 0.81 | MAPT (0.49) | MAPTATRALDH1A1LMNAMEN1 | |
| SCHEMBL11021081 | 0.80 | CA12 (0.43) | MAPTATRKMT2ACHEK2TRPV4 | |
| SCHEMBL11018186 | 0.80 | CYP3A4 (0.48) | ATRPKN1PKN2CFBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |