Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021081 | 0.92 | CA12 (0.43) | ATRCA12CA1CA2CA9 | |
| SCHEMBL11022217 | 0.91 | ATR (0.53) | ATRMETAP2METAP1PKN1PKN2 | |
| SCHEMBL11020318 | 0.89 | CA12 (0.54) | ATRCA12CA1CA2CA9 | |
| SCHEMBL11021741 | 0.88 | ATR (0.44) | ATRMETAP2METAP1PKN1PKN2 | |
| SCHEMBL11021240 | 0.88 | MAPT (0.46) | ATRMETAP2METAP1PKN1PKN2 | |
| SCHEMBL11022213 | 0.83 | ATR (0.44) | ATRSCDMAPTTRPV4 | |
| SCHEMBL11018186 | 0.82 | CYP3A4 (0.48) | ATRPKN1PKN2SCD | |
| SCHEMBL11018070 | 0.81 | METAP2 (0.44) | ATRMETAP2METAP1PKN1PKN2 | |
| SCHEMBL11020313 | 0.81 | CA2 (0.54) | ATRCA12CA1CA2CA9 | |
| SCHEMBL11021674 | 0.81 | METAP2 (0.46) | ATRMETAP2METAP1PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |