Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018637 | 0.92 | ALDH1A1 (0.44) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL11017899 | 0.91 | CHEK2 (0.50) | L3MBTL1HDAC6NPC1RAB9ACHEK2 | |
| SCHEMBL11019284 | 0.90 | CHEK2 (0.55) | CHEK2 | |
| SCHEMBL11018781 | 0.88 | ATR (0.52) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL11017978 | 0.87 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL11017892 | 0.83 | MAPT (0.44) | KDM4EALDH1A1LMNANPC1RAB9A | |
| SCHEMBL11019277 | 0.82 | CHEK2 (0.46) | KDM4EALDH1A1LMNANPC1RAB9A | |
| SCHEMBL11018866 | 0.81 | MAPT (0.44) | KDM4EALDH1A1LMNAHTTATR | |
| SCHEMBL11019646 | 0.81 | MAPT (0.47) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL10765896 | 0.81 | ATR (0.48) | KDM4EALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |